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- Identification of POLQ as a chromosomal instability-associated . . .
Our framework figured out that DNA polymerase theta (POLQ) facilitated CIN in HCC and exhibited higher levels of expression in HCC compared with normal tissues Moreover, the increased POLQ expression was closely linked to the poor prognosis of patients with HCC
- Identification of POLQ as a key gene in cervical cancer progression . . .
Based on the results of integrated bioinformatics analysis, the deGs structural maintenance of chromosomes 4 (SMc4), aTPase family, aaa domain‐containing 2 (aTad2) and dna polymerase θ (POLQ) were identified as hub genes in the PPI network and were involved in the first significant subnetwork
- Identification of POLQ as a chromosomal instability-associated . . .
We present a compendium of 17 copy number signatures that characterize specific types of CIN, with putative aetiologies supported by multiple independent data sources The signatures predict drug
- Identification and Targeting of POLQ-Associated Hereditary . . . - PubMed
This study identifies POLQ as a pathogenic gene in hereditary CRC, unveiling a novel POLQ-type CRC driven by TMEJ hyperactivation Screening for POLQ mutations in patients with hereditary adenomas or early-onset CRC would benefit early diagnosis and personalized therapy for POLQ-associated CRC, whil …
- Identification of POLQ as a chromosomal instability-associated . . .
Identification of POLQ as a chromosomal instability-associated biomarker for hepatocellular carcinoma Genes Diseases ( IF 6 9) Pub Date : 2025-02-04, DOI: 10 1016 j gendis 2025 101553
- Anemarchalconyn, a natural alkyne ketone compound, inhibits HCC cell . . .
SL-001 exhibited robust anti-proliferative effects on hepatocellular carcinoma (HCC) cells, surpassing the efficacy of the current standard treatment, sorafenib The anti-HCC effect of SL-001 was associated with downregulation of POLQ, a key protein involved in alternative DNA repair pathways
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