- CC-90009, a novel cereblon E3 ligase modulator, targets acute myeloid . . .
Here, we present the identification of a first-in-class GSPT1-selective cereblon E3 ligase modulator, CC-90009 Biochemical, structural, and molecular characterization demonstrates that CC-90009 coopts the CRL4CRBN to selectively target GSPT1 for ubiquitination and proteasomal degradation
- A Novel Cereblon E3 Ligase Modulator Eradicates Acute Myeloid Leukemia . . .
Here we report that the novel cereblon E3 ligase modulator (CELMoD) CC-90009, which causes degradation of the translation termination factor G1 to S phase transition protein 1 (GSPT1) and downstream activation of ISR, is potent against primary AML both in vitro and in vivo, and reduces self-renewing LSCs in preclinical xenograft models for
- Blood：新型CRBN E3连接酶调节剂CC-90009，靶向促进 . . .
在该研究中，Christine等鉴定了一种一流的GSPT1选择性脑蛋白E3连接酶调节剂CC-90009。
- CC-90009, a Novel Cereblon E3 Ligase Modulator, Targets GSPT1 for . . .
Here, we present the identification of a novel GSPT1-selective CELMoD, CC-90009, and the mechanistic rationale for its clinical development in relapsed or refractory (R R) AML (CC-90009-AML-001; NCT02848001)
- CC-90009, a novel cereblon E3 ligase modulator targets acute myeloid . . .
Here, we present the identification of a first-in-class GSPT1-selective cereblon E3 ligase modulator, CC-90009 Biochemical, structural and molecular characterization demonstrates that
- Unleashing CC-90009: Targeting GSPT1 for Acute Myeloid . . . - Patsnap
The research abstract describes the development of a novel cereblon E3 ligase modulator (CELMoD), CC-90009, designed to selectively target the translation termination factor GSPT1 for degradation via the CRL4CRBN E3 ubiquitin ligase complex
- CC-90009, a novel cereblon E3 ligase modulator, targets acute myeloid . . .
Here, we present the identification of a first-in-class GSPT1-selective cereblon E3 ligase modulator, CC-90009 Biochemical, structural, and molecular characterization demonstrates that CC-90009 coopts the CRL4CRBN to selectively target GSPT1 for ubiquitination and proteasomal degradation
- CC-90009, a novel cereblon E3 ligase modulator targets . . .
Here, we present the identification of a first-in-class GSPT1-selective cereblon E3 ligase modulator, CC-90009 Biochemical, structural and molecular characterization demonstrates that CC-90009 co-opts the CRL4CRBN to selectively target GSPT1 for ubiquitination and proteasomal degradation
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